XWH - 12 - 1 - 0320 TITLE : Cellular Basis for Learning Impairment in Fragile X Syndrome

AWARD NUMBER: W81XWH-12-1-0320 TITLE: Cellular Basis for Learning Impairment in Fragile X Syndrome PRINCIPAL INVESTIGATOR:

s 1. Keil, S.A. & Larson, J. Impaired olfactory discrimination learning in fragile X knockout mice. Abstracts, Society for Neuroscience (2014) Program no. 699.10. (APPENDIX 3) 2. Davis, C., Demars, M., Larson, J., & Lazarov, O. Deficits in adult neurogenesis in fragile X syndrome. Abstracts, Society for Neuroscience (2015) Program No. 491.06. (APPENDIX 4)

Award Number : W 81 XWH - 09 - 1 - 0320 TITLE : Reduced Toxicity Breast Cancer Therapy : Changing the “ Or ” to “ And ” in Dual Targeted Therapeutics

XWH - 11 - 1 - 0626 TITLE : Treatment of Fragile X Syndrome with a Neuroactive Steroid

Work in recent years has revealed an abundance of possible new treatment targets for fragile X syndrome (FXS). The use of animal models, including the fragile X knockout mouse which manifests a phenotype very similar to FXS in humans, has resulted in great strides in this direction of research. The lack of Fragile X Mental Retardation Protein (FMRP) in FXS causes dysregulation and usually overe...

Obsessive-Compulsive Disorder and Hyperphagia in a Boy with Fragile X Syndrome: A Case Report

Objective: Fragile X syndrome is the second etiology for inherited mental retardation. It may concomitant with other psychiatric disorders. Intellectual disability (ID) is a state of functioning that typically begins in childhood and is characterized by limitations in intelligence and adaptive skills. We intend to introduce a male young patient with Fragile X syndrome and Obsessive-Compulsive d...

گزارش یک مورد سندرم ایکس شکننده همراه با ناهنجاری انگشتان

  Fragile X Syndrome, the most common cause of inherited mental retardation, results from mutation in fragile X mental retardation gene (FMR1) on long arm of X chromosome, Xq27.3. Clinical features include moderate to severe mental retardation without neurologic deficit, long face, large ears, prominent jaw, macro-orchidism, attention deficit, behavior di...